Endocrine Abstracts

Introduction: Recent advance of genetic testing has contributed to the diagnosis of hereditary pheochromocytoma and paraganglioma (PPGL). Germline mutations in MYC associated factor X(MAX) are responsible for 1.1% of these PPGL; the median age at onset is 33 years and no reliable penetrance estimation is available for MAX-carriers. The authors present the case of a synchronous bilateral pheochromocytoma that prompted the discovery of a proband of MAX mutation and three other r...

Introduction: Recent studies suggest that the use of dipeptidyl peptidase 4 inhibitors (DPP-4i) may be associated with an increased risk of developing bullous pemphigoid; which has led to publication of several pharmacovigilance alerts.Objectives: To characterize the potential association between the use of DPP-4i and the risk of developing bullous pemphigoid.Material & methods: Observational, retrospective study based on clini...

Introduction: There are known biological differences between men and women in coronary heart disease. It is important to know these differences in order to avoid inequalities in prevention, diagnosis and treatment of this pathology.Methods: We designed a retrospective, descriptive study in which we included all diabetic patients admitted to 3 different hospitals in Cádiz province with acute coronary syndrome and diabetes in 2016. Demographic data an...

Objectives: To evaluate the psychosocial aspects in a group of patients in follow-up in specific consultation of bariatric surgery prior to the intervention and in a group of patients intervened.Methods: Cross-sectional study of patients in follow-up in the specific morbid obesity consultation of the University Hospital Puerta del Mar (Cádiz) not intervened and a group intervened and in a group intervened, at 6–12 months of follow-up.<p cla...

Introduction: Diabetic ketoacidosis (DKA) is an endocrine emergency and the leading cause of morbi-mortality in children with type 1 diabetes mellitus (1DM). DKA treatment is still controverse, mainly regarding hydroelectrolytic replacement and insulin dose.Aims: To evaluate efectiveness and safety of our tertiary centre protocol in DKA treatment, which included initial volume expansion with isotonic saline in the first two hours followed by 0.45% sodium...

Introduction: Autoimmune Addison disease requires lifelong glucocorticoid and mineralocorticoid replacement. Optimal therapy is not standardized and must balance adequate hormone substitution with prevention of treatment-related complications.Objective: Assessment of patients followed at our department: epidemiology, associated conditions, treatment, cumulative hydrocortisone dose and comorbidities.Methods: Review of clinical recor...

Introduction: In most cases, adrenal masses are non-functioning adrenocortical adenomas. On ‘Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline’ published in 2016, the experts ‘suggest against repeated hormonal work-up in patients with a normal hormonal work-up at initial evaluation unless new clinical signs of endocrine activity appear or there is worsening of comorbidities’.C...

Introduction: Multiple endocrine neoplasia (MEN) syndromes are rare entities characterized by the occurrence of tumors involving two or more endocrine glands in a single patient. These syndromes are classified as type 1 or 2 according to specific phenotypic characteristics. MEN2 encompasses three different subtypes: MEN2A, MEN2B and familial medullary thyroid carcinoma. More recently a syndrome related to mutations in the CDKN1B gene has been described – the syndrome of m...

Background: Adolescent girls with type 1 diabetes (T1DM) have a higher incidence of metabolic risk factors like hypertension, dyslipidemia, non-alcoholic hepatic steatosis (NASH), abdominal adiposity and polycystic ovarian syndrome (PCOS) when compared with their non-diabetic peers. Moreover, metabolic risk factors seem to appear even in T1DM girls without overweight or obesity. We aimed to determine the prevalence of several metabolic risk factors in adolescent T1DM females, ...

Background: Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a autosomal recessive disorder with only up to 500 reported cases. It is characterized by generalized absence of fat since birth and severe metabolic derangements such as insulin resistance, hyperglycemia and dyslipidemia. Diabetes mellitus generally develops during the second or third decade of life. This is a rare clinical condition, with worldwide prevalence of 1 in 10 million people and incidence of 1:500.000...